Heritability of Heart Rate upon Stimulation in Members of Families with History of Hypertension
Bibliographic record
Abstract
P139 Objectives:Heart rate (HR) is an independant risk factor for cardiovascular disease and believed to be in part genetically determined. We have studied the heritability of HR in members of large families with history of hypertension (HT). In addition, candidate genes involved in cardiovascular regulation were tested. Methodology:Under study, families of the Saguenay-Lac St-Jean of the province of Quebec showed a higher prevalence of HT in all age groups than the national and provincial population and high degree of kinship. Using impedance plethysmography HR was recorded during posture and mental stress tests. DNA extracted from blood leucocytes was analysed by PCR for the ACE and TNF-α genes. Heritability and linkage were analysed with the FCOR and SIBPAL programs of the SAGE package. Results: HR changed significantly from the resting supine position to standing, sitting, 2 min. and 4 min. into the math test and returned to baseline after 10 min of rest. Heritability (h 2 ) estimates are shown in the table below. Indexes of h 2 were significant during math test and the recovery period (*:p<0.05,***:p<0.001). Only the ACE I/D polymorphism was suggestively linked (p=0.03) to HR and only for the post-test period. Conclusions: A significant genetic component of HR was observed only during stimulation by the mental stress test. At the post-test period, a part of the heritable component appeared to be linked to the ACE locus. (Supported by MRC and NIH SCOR program)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".