The long-Term Effect of Juvenile Stressor Exposure and Access to Palatable Food: Alterations in Dopamine and Ghrelin Signalling
Bibliographic record
Abstract
Juvenile stressor exposure increases the susceptibility to anxiety-like characteristics in adulthood and it is thought that the consumption of palatable food can dampen the HPAaxis, in part, through the mesolimbic pathway.Ghrelin, an orexigenic peptide, increases food intake and has a role in stress-induced preference for palatable food by modulating dopamine release in the reward pathway.We hypothesize that the combination of juvenile stressor exposure and access to palatable food sensitizes the reward pathway, which will be manifested by altered dopamine receptor mRNA expression and enhanced sensitivity to ghrelin in adulthood.Findings revealed that access to palatable food ameliorated the anxiogenic effects of juvenile stressor exposure in adulthood however at the cost of increased adiposity.Interestingly, our findings displayed a lack of association between the upregulation of dopamine receptor mRNA expression occurring at nucleus accumbens to highly rewarding stimuli (cookie dough and cocaine) in previously stressed rats with access to palatable food.Juvenile stressor exposure enhanced ghrelin signalling for highly hedonic food whereas access to palatable food, regardless of stressor exposure, blunted ghrelin sensitivity.iii
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".