P175. Clinical outcome of ulcerative colitis with mucosal healing demonstrated by white light endoscopy but with subtle abnormalities detected by high definition iSCAN endoscopy
Bibliographic record
Abstract
especially in patients with indefinite FC values, for assessment of disease activity in a real-life IBD cohort.Methods: Three hundred and three consecutive IBD patients were enrolled and participated in a 1 year prospective follow-up study.Patients were assessed during routine outpatient clinic visits or when a flare occurred.Clinical disease activity was scored by Harvey Bradshaw index or Simple Clinical Colitis Activity Index, also C-reactive protein (CRP) and FC were determined.We defined FC levels between 100-250 µg/g as inconclusive.Endoscopic evaluation was performed when indicated.Endoscopic disease activity was determined by the Simple Endoscopic Score-CD and Mayo endoscopic subscore in ulcerative colitis (UC).Clinical activity index, CRP and FC were combined into a new combination score and evaluated in the cohort of patients who underwent an endoscopy.Patients with inconclusive FC values were re-classified with the combination score.Results: Inconclusive FC values were present in 24% (CD) and 15% (UC) of the patients.In both CD and UC more patients had active disease according to the combination score (47% and 39%) than with assessment of FC alone (26% and 32%).In CD, the combination score could predict endoscopic disease activity with sensitivity of 79%, specificity of 58% (positive predictive value (PPV) 54%, negative predictive value (NPV) 82%).In UC this was 85% and 57% (PPV 88%, NPV 50%).All patients with inconclusive FC values could be classified with the new combination score.Conclusions: In our real-life cohort of IBD patients, a substantial part of patients has inconclusive FC values.The combination of FC with clinical activity indices or CRP helped to classify disease activity in these patients.We think that the concept of combining non-invasive markers is an interesting new tool in the search for reliable and easy to use surrogate markers for endoscopy in daily clinical practice.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".