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Record W4236942225 · doi:10.1002/9781444341294.ch23

Autoimmune Hepatitis and Overlap Syndromes

2011· other· en· W4236942225 on OpenAlexaff
Gideon M. Hirschfield, E. Jenny Heathcote

Bibliographic record

Venuenot available
Typeother
Languageen
FieldMedicine
TopicLiver Diseases and Immunity
Canadian institutionsUniversity of TorontoUniversity Health NetworkToronto Western Hospital
Fundersnot available
KeywordsAutoimmune hepatitisMedicinePrimary sclerosing cholangitisPrimary biliary cirrhosisPrednisoneAzathioprineOverlap syndromeHepatitisAsymptomaticImmunologyLiver diseaseDiseaseGastroenterologyInternal medicine

Abstract

fetched live from OpenAlex

Autoimmune hepatitis is a chronic relapsing and remitting hepatitis, seen across all ages and in both genders. Disease severity ranges from mild asymptomatic inflammation to acute liver failure. The syndrome of autoimmune hepatitis lacks a definitive diagnostic test and disease is characterized broadly by transaminitis, hypergammaglobulinaemia and the presence of autoantibodies. Histology whilst not unique in its own right includes a plasma cell rich interface hepatitis. Exclusion of drug-induced liver injury and Wilson's disease is important. Therapy with prednisone and azathioprine is successful in the majority of cases in terms of inducing disease remission and preventing disease relapse. Some patients may have outlier features of other autoimmune liver diseases, including primary biliary cirrhosis and primary sclerosing cholangitis. Overlap syndromes are, however, not distinct diseases.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.012
Threshold uncertainty score0.039

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.003
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0120.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.242
Teacher spread0.224 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2011
Admission routes1
Has abstractyes

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