Investigating British Columbia wild mushrooms for growth-inhibitory activity
Bibliographic record
Abstract
This thesis documents that crude extracts from B.C. wild mushrooms possess potent growth-inhibitory properties.In addition, this work shows, for the first time, that ethanol extracts from Piptoporus betulinus and Ganoderma applanatum have a strong growthinhibitory activity and that methanol extracts of Echinodontium tinctorium, a previously untested fungus, exhibits growth-inhibitory activity as well.In addition to human cervical cancer HeLa cells, E. tinctorium extracts also exhibited a growth-inhibitory effect on human breast, ovarian, liver, lung, and colon cancer cell lines.Upon purification using Sephadex LH-20 gel filtration chromatography, two distinct growth-inhibitory compounds were documented: a higher molecular weight growth-inhibitory compound(s), likely to contain carbohydrate and a lower molecular weight growth-inhibitory compound(s), likely to be a small molecule.This thesis provides the foundation work to allow further purification and characterization of these potentially novel growth-inhibitory compound(s) from E. tinctorium, an essential step towards future therapeutic use.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".