Investigating British Columbia wild mushrooms for growth-inhibitory activity
Bibliographic record
Abstract
This thesis documents that crude extracts from B.C. wild mushrooms possess potent growth-inhibitory properties. In addition, this work shows, for the first time, that ethanol extracts from Piptoporus betulinus and Ganoderma applanatum have a strong growthinhibitory activity and that methanol extracts of Echinodontium tinctorium, a previously untested fungus, exhibits growth-inhibitory activity as well. In addition to human cervical cancer HeLa cells, E. tinctorium extracts also exhibited a growth-inhibitory effect on human breast, ovarian, liver, lung, and colon cancer cell lines. Upon purification using Sephadex LH-20 gel filtration chromatography, two distinct growth-inhibitory compounds were documented: a higher molecular weight growth-inhibitory compound(s), likely to contain carbohydrate and a lower molecular weight growth-inhibitory compound(s), likely to be a small molecule. This thesis provides the foundation work to allow further purification and characterization of these potentially novel growth-inhibitory compound(s) from E. tinctorium, an essential step towards future therapeutic use.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".