Report of Seven Cases of Langerhans Cell Histiocytosis in a Single Hospital in Japan
Bibliographic record
Abstract
Langerhans cell histiocytosis (LCH), which shows a variable clinical presentation, is a disease that involves the proliferation of histiocytes. LCH occurs at any age and can affect a single system or multiple systems. The successful and accurate diagnosis of cases involving multiple organs requires a multidisciplinary approach. Since LCH receives limited attention, failure to recognize this disease in the early pediatric age can result in progression into adulthood. This study presents the clinical manifestations, imaging findings, pathological and cytological features, treatment strategies and prognoses of seven cases of LCH that are managed in a single hospital over the last 12 years. The ages of the patients ranged from 1 to 58 years. The sites at which LCH developed included the skin, lung, bone, lymph nodes and brain: one patient (adult male) had single-system/single-site LCH, three patients (adult male, adult female and girl) had single-system/multi-site LCH and three patients (adult female and two girls) had multi-system/multi-site LCH. BRAF V600E mutation was suggested in an adult female with multi-system/multi-site LCH and an adult male with single-system/multi-site LCH. We also discuss the pathogenesis and review the relevant literature. J Med Cases. 2019;10(7):209-217 doi: https://doi.org/10.14740/jmc3325
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".