RETRACTED: Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen
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Post-publication record
OpenAlex flags this work as retracted, but it carries no matching Retraction Watch record in this frame.
Machine scores (provisional)
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- Teacher spread
- 0.217 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
This preprint is retracted at the authors' request. Since its publication, the authors have become aware that the published synthesis does not provide the title compound, instead generating the characterization-similar glycosyl ester of serine. The authors have submitted a corrected version of this article to ChemRxiv (now posted: 10.26434/chemrxiv-2025-zj3h4) to correct the chemical record and are deeply sorry for any wasted effort this original report might have caused others. The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most reliably accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-functionalized serine acceptor to form the target in moderate yields. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.
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The record
- Venue
- ChemRxiv
- Topic
- Carbohydrate Chemistry and Synthesis
- Field
- Chemistry
- Canadian institutions
- University of Windsor
- Funders
- Universities Space Research AssociationNatural Sciences and Engineering Research Council of CanadaMitacsWindsor Cancer Centre Foundation
- Keywords
- GlycopeptideGlycosylationSerineChemistryCombinatorial chemistryAcceptorBiochemistryPhosphorylationPhysics
- Has abstract in OpenAlex
- yes