Short chain fatty acids modulate flagella expression in enterohemorrhagic Escherichia coli
Bibliographic record
Abstract
During passage through the human gastrointestinal tract, enterohemorrhagic Escherichia coli (EHEC) encounters numerous stresses. EHEC utilizes various strategies to combat and survive these host assaults and possibly employs them as cues about the local microenvironment to enhance infection. This investigation looks at how exposure to changing concentrations of short chain fatty acid mixtures (SCFA) associated with passage through the human small (SI) and large intestines (LI) affects EHEC flagella expression and motility. In addition, the study also examines several two component systems for their involvement with SCFA-induced flagella regulation. The results indicate that SCFA mixture typical of SI may cue increased EHEC flagellar expression and function while SCFA mixture typical of LI, the site of EHEC colonization, may promote diminished flagella expression and function. Overall, this study contributes to our knowledge on how EHEC sense and respond to host environmental signals in a way that may promote to infection.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".