Faculty Opinions recommendation of FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
Bibliographic record
Abstract
Endocytosis mediates the cellular uptake of micronutrients and turnover of plasma membrane proteins.Clathrin-mediated endocytosis (CME) is the major uptake pathway in resting cells1, but several Clathrin-independent endocytic (CIE) routes exist in parallel2,3.One such pathway, fast Endophilin-mediated endocytosis (FEME), is not constitutive but triggered upon activation of certain receptors including β1 adrenergic receptor (β1-AR)4.FEME activates promptly following stimulation as Endophilin is pre-enriched by the Pi(3,4)P 2 -binding protein Lamellipodin (Lpd)4,5.However, in the absence of stimulation, Endophilin foci abort and disassemble after a few seconds.Looking for additional proteins involved in FEME, we found that 20 out of 65 BAR domaincontaining proteins tested colocalized with Endophilin spots.Among them, FBP17 and CIP4 prime the membrane of resting cells for FEME by recruiting the 5'-lipid phosphatase SHIP2 and Lpd to mediate local production of Pi(3,4)P 2 and Endophilin pre-enrichment.Membrane-bound GTP-loaded Cdc42 recruits FBP17 and CIP4, before being locally deactivated by RICH1 and
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.212 | 0.103 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".