Regulation of Protein Translation and Cell Cycle Processes by Reversible Protein Phosphorylation in Response to Dehydration in the African Clawed Frog
Bibliographic record
Abstract
The primarily aquatic African clawed frog, Xenopus laevis, has adapted to endure substantial dehydration, partly by entering a state of hypometabolism.This thesis focuses on two processes targeted by the central protein kinase Akt (that is inhibited during dehydration) -protein translation and the cell cycle.Results suggest that dehydration leads to mTORC1 inhibition via PRAS40 activation in both liver and skeletal muscle, thereby suppressing protein synthesis.Suppression of Akt also allows activation of p21 and p27 cell cycle inhibitors to promote cell cycle arrest in liver.Analysis of multiple protein components shows that cell cycle arrest is actively facilitated in liver, but not in muscle.Regulation of liver kinases and phosphatases led to hypophosphorylation of Rb which inhibits E2F1-induced transcription of genes required for cell cycle progression.Overall, during dehydration, frogs suppress protein translation in liver and muscle, and show regulated cell cycle arrest in liver, a proliferative tissue.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".