Mitigation of Azathioprine-induced Testicular Atrophy by Taurine; An Impact on Inflammation, Oxidative Perturbations and Apoptosis
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Post-publication record
- Nature
- Retraction
- Reason
- Duplication of/in Article;
- Date
- 3/1/2018 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.277 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Azathioprine (AZA) is an effective anticancer drug, but some cases of testicular toxicity have been reported. The aim of this work was to investigate the protective effects of taurine (TAU), a reported antioxidant and antiinflammtory peptide, against AZA-induced testicular dysfunction in male rats and ascertain the contributing mechanisms. Forty adult male rats were allocated into four equal groups; (i) normal control rats, (ii) TAU group (100 mg/kg b.w/ day for ten weeks, (iii) AZA group (10 mg/day for four weeks); (iv) TAU/AZA group. As expected, AZA caused increased DNA damage in the testes, and alterations in sex hormones and sperm quality, including sperm count, viability, and motility. Moreover, testicular tissue from the AZA-treated group had increased levels of oxidative stress indicators, MDA, and reduced glutathione (GSH) levels, and decreased activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). These deleterious events were accompanied by upregulated levels of the proinflammatory cytokines, tumor necrosis factor-alpha (TNF-), interleukin-1beta (IL-1), and proapoptotic marker; caspase-9, together with decreased Bcl-2 expression. In contrast, TAU pretreatment significantly abrogated these toxic effects which were confirmed histologically.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Canadian Journal of Physiology and Pharmacology
- Topic
- Aldose Reductase and Taurine
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- —
- Keywords
- TaurineAtrophyInflammationOxidative stressApoptosisAzathioprineTesticular atrophyEndocrinologyOxidative phosphorylationMedicineInternal medicineBiologyDiseaseBiochemistry
- Has abstract in OpenAlex
- yes