Regulation of Anti-Apoptotic Pathways in Skeletal Muscle and Liver of an Estivating Species, Xenopus laevis
Bibliographic record
Abstract
This study investigated the anti-apoptotic pathways activated during dehydration and estivation of the African clawed frog, Xenopus laevis.Staying immobile for a significant period of time can cause serious tissue atrophy in non-adapted animals.To preserve skeletal muscle and liver mass, certain metabolic pathways with functions in cell preservation and protection must be activated.This study focused on two families of transcription factors, NF-κB and STAT whose target genes include those with antiapoptotic functions.The data indicated an upregulation of the NF-ᴋB pathway in liver of dehydrated frogs along with downstream targets Bcl-xL and c-IAP.STAT3 appeared to be active in liver whereas STAT5 was active in skeletal muscle.Relative levels of the NF-κB and STAT downstream target Bcl-2 were elevated in response to dehydration.Analysis of pro-and anti-apoptotic microRNAs indicated that these contribute to posttranscriptional regulation of mRNA transcripts that encode proteins with roles in cell survival.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".