COPD SIG: Poster Session 2
Bibliographic record
Abstract
Early life infection with RSV is associated with development and exacerbations of asthma.Airway vascularity and pro-angiogenic factors (VEGF, bFGF, angiogenins) are upregulated in the airways of asthmatics.We investigated whether early life pneumoviral infection leads to the development of pulmonary angiogenesis, and whether this is due to viral-induced up-regulation of proangiogenic factors in the lung.Methods Lung tissues were collected following primary or secondary infection of newborn BALB/c mice with pneumonia virus of mice (PVM).Viral titre and expression levels of pro-angiogenic factors in lungs were determined by qPCR.Angiogenesis was quantified by immunohistochemistry using the angiogenic markers CD31 (PCAM-1) and von Willebrand Factor (vWF).Results Angiogenesis was apparent 14 days post infection (dpi) (CD31 = 0.3 Ϯ 0.1, vWF = 0.2 Ϯ 0.2), peaked at 28 dpi (CD31 = 30.8Ϯ 3.6, vWF = 38.4Ϯ 5.3) and regressed by 35 dpi (CD31 = 0.3 Ϯ 0.3, vWF = 0).A secondary infection at day 82 re-activated angiogenesis by day 96 (vWF = 46.8Ϯ 6.7).Detection of pro-angiogenic factors (VEGF, Ang1 and Tie2) in the lung correlated with the observed angiogenesis.Conclusions Early life pneumoviral infection induces the development of angiogenesis which is spatially associated with the airways.This model is the first to demonstrate a specific link between early life respiratory viral infection and the induction of angiogenesis in the lung.Supported by The Hunter Medical Research Institute, CRC for Asthma and Airways and NH&MRC. Conflict of Interest No.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.003 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.602 | 0.411 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".