Novel Interventions for Heat/Exercise Induced Sudden Death and Fatigue
Bibliographic record
Abstract
This study was designed to identify human mutation that caused Exertional and/or environmental heat stroke (EHS) and exertional rhabdomyolysis (ER) and to develop new interventions to prevent EHS and ER. We identified RyR1 mutations as a major cause of exertional rhabdomyolysis. 82% of the individuals that were enrolled in the study that had a family history of MH were positive for disease-associated mutations in the RYR1 gene, while 10.5% of index cases enrolled for a history of unexplained or recurrent ER were positive for disease-associated mutations in the RYR1 gene. All of these cases were CHCT positive. Although AICAR was not effective in preventing isoflurane or heat induced episodes in hyper-metabolic response in pigs homozygous for an RyR1 mutation, AICAR was effective in preventing heat-induced hyper-metabolic responses in the heterozygous mouse model of malignant hyperthermia.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".