Patient-derived induced pluripotent stem cells — Bridging the gaps between preclinical and clinical effectiveness in brain illness?
Bibliographic record
Abstract
Patient-derived induced pluripotent stem cells -Bridging the gaps between preclinical and clinical effectiveness in brain illness?At present, patient-derived central nervous system (CNS) tissue is often only available post-mortem.While these tissues can be helpful during autopsy and when confirming a clinical diagnosis, the obvious barriers in accessing primary human CNS tissue in live patients presents an impediment to developing patient-specific personalized approaches in clinical medicine.Furthermore, ideal access to post-mortem tissues is often limited for both clinicians and researchers, and a delayed post-mortem interval can significantly impact tissue and cellular integrity.As a result, animal models of CNS diseases are frequently used in research and are heavily relied upon when studying disease mechanisms and identifying possible treatment strategies.While certain imaging techniques (CT, MRI, PET, etc) can provide valuable clinical information in vivo, their lack of specificity and detailed resolution at the microscopic level is insufficient in providing detailed cellular mechanisms related to pathophysiological mechanisms of neurodegenerative diseases.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.046 | 0.046 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.008 |
| Scholarly communication | 0.006 | 0.011 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.004 | 0.005 |
| Insufficient payload (model declined to judge) | 0.009 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".