Human neutrophils express the high‐affinity receptor for immunoglobulin E (FceRI): role in asthma
Bibliographic record
Abstract
ABSTRACT Polymorphonuclear neutrophils (PMNs) are important effector cells in host defense and the inflammatory response to antigen. The involvement of PMNs in inflammation is mediated mainly by the Fc receptor family, including IgE receptors. Recently, PMNs were shown to express two IgE receptors (CD23/FcsRII and galectin‐3). In allergic diseases, the dominant role of IgE has been mainly ascribed to its high‐affinity receptor, FcsRI. We have examined the expression of FcsRI by PMNs. mRNA and cell surface expression of FcsRIa chain was identified on PMNs from asthmatic subjects. Furthermore, preincubation with human IgE Fc fragment blocks completely the binding of anti‐FcsRIa chain (mAb15–1) to human PMNs. Conversely, preincubation of PMNs with mAb15–1 inhibits significantly the binding of IgE Fc fragment to PMNs, indicating that IgE bound to the cell surface of PMNs mainly via the FcsRI. Peripheral blood and bronchoalveolar lavage (BAL) PMNs from asthmatic subjects also express intracellular FcsRIa and β chain immunoreactivity. Engagement of FcsRI induces the release of IL‐8 by PMNs. Collectively, these observations provide new evidence that PMNs express the FcsRI and suggest that these cells may play a role in allergic inflammation through an IgE‐dependent activation mechanism.—Gounni, A. S., Lamkhioued, B., Koussih, L., Ra, C., Renzi, P. M, Hamid, Q. Human neutrophils express the high‐affinity receptor for immunoglobulin E (FcsRI): role in asthma. FASEB J. 15, 940–949 (2001)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".