P176. Irritable bowel syndrome frequency in Inflammatory Bowel Disease during both clinical and deep remission and its association with fecal calprotectin
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Bibliographic record
Abstract
especially in patients with indefinite FC values, for assessment of disease activity in a real-life IBD cohort. Methods: Three hundred and three consecutive IBD patients were enrolled and participated in a 1 year prospective follow-up study. Patients were assessed during routine outpatient clinic visits or when a flare occurred. Clinical disease activity was scored by Harvey Bradshaw index or Simple Clinical Colitis Activity Index, also C-reactive protein (CRP) and FC were determined. We defined FC levels between 100-250 g/g as inconclusive. Endoscopic evaluation was performed when indicated. Endoscopic disease activity was determined by the Simple Endoscopic Score-CD and Mayo endoscopic subscore in ulcerative colitis (UC). Clinical activity index, CRP and FC were combined into a new combination score and evaluated in the cohort of patients who underwent an endoscopy. Patients with inconclusive FC values were re-classified with the combination score. Results: Inconclusive FC values were present in 24% (CD) and 15% (UC) of the patients. In both CD and UC more patients had active disease according to the combination score (47% and 39%) than with assessment of FC alone (26% and 32%). In CD, the combination score could predict endoscopic disease activity with sensitivity of 79%, specificity of 58% (positive predictive value (PPV) 54%, negative predictive value (NPV) 82%). In UC this was 85% and 57% (PPV 88%, NPV 50%). All patients with inconclusive FC values could be classified with the new combination score. Conclusions: In our real-life cohort of IBD patients, a substantial part of patients has inconclusive FC values. The combination of FC with clinical activity indices or CRP helped to classify disease activity in these patients. We think that the concept of combining non-invasive markers is an interesting new tool in the search for reliable and easy to use surrogate markers for endoscopy in daily clinical practice.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it