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Record W4240685303 · doi:10.3747/co.v18is2.939

Corrigendum: Progression-Free Survival in Advanced Ovarian Cancer: A Canadian Review and Expert Panel Perspective

2011· review· en· W4240685303 on OpenAlexaffvenueabout
Amit M. Oza, Vincent Castonguay, Daliah Tsoref, Iván Díaz-Padilla, Katherine Karakasis, Helen Mackay, Stephen Welch, J. Weberpals, Paul Hoskins, M. Plante, Diane Provencher, K. Tonkin, Al Covens, Prafull Ghatage, Jean‐Pierre Grégoire, Holger W. Hirte, Daniel Miller, Barry P. Rosen, J. Bentley, J. Maroun, Marc Buyse, C. Coens, Maureen Brady, Gavin Stuart

Bibliographic record

VenueCurrent Oncology · 2011
Typereview
Languageen
FieldMedicine
TopicColorectal Cancer Treatments and Studies
Canadian institutionsUniversity of British ColumbiaDalhousie UniversityHamilton Health SciencesBC Cancer AgencyHôtel-Dieu de QuébecJuravinski Cancer CentreSunnybrook Health Science CentrePrincess Margaret Cancer CentreOttawa HospitalLondon Health Sciences CentreUniversité de MontréalUniversité Laval
Fundersnot available
KeywordsMedicineColorectal cancerClinical endpointRandomized controlled trialOncologyProgression-free survivalOverall survivalConfoundingOvarian cancerClinical trialInternal medicineCancerIntensive care medicine

Abstract

fetched live from OpenAlex

In recent years, significant advances have been made in the management of metastatic colorectal cancer. Traditionally, an improvement in overall survival has been considered the “gold standard”—the most convincing measure of efficacy. However, overall survival requires larger patient numbers and longer follow-up and may often be confounded by other factors, including subsequent therapies and crossover. Given the number of active therapies for potential investigation, demand for rapid evaluation and early availability of new therapies is growing. Progression-free survival is regarded as an important measure of treatment benefit and, compared with overall survival, can be evaluated earlier, with fewer patients and no confounding by subsequent lines of therapy. The present paper reviews the advantages, limitations, and relevance of progression-free survival as a primary endpoint in randomized trials of metastatic colorectal cancer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.043
Threshold uncertainty score0.086

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.009
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.005
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0020.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0150.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.273
GPT teacher head0.485
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2011
Admission routes3
Has abstractyes

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