Bibliographic record
Abstract
Cell survival requires adaptive responses to transient increases of reactive oxygen species (ROS) during stress.The nuclear factor-erythroid 2-like factors (Nrf1 and Nrf2) and Maf cofactors transactivate genes with antioxidant response elements (ARE) to coordinate distinct metabolic pathways following ROS.Nrf2 predominantly responds to oxidative stress and electrophiles to regulate glutathione biosynthesis, while Nrf1 regulates proteasome induction.This thesis shows nuclear accumulation of the longer forms of Nrf1 (p120-and p95-Nrf1) in response to ER stress mediated by tunicamycin (TUN), thapsigargin (THP), and dithiothreitol (DTT) in HEK293T cells.Nrf2, as opposed to Nrf1, was induced by the oxidative stressor antimycin A (AA) in the absence of BiP induction while both Nrfs accumulated in the nuclei from DTT-mediated redox stress.Cell stress was monitored using the H2DCFDA, MTT and PI assays.These results are the first to indicate Nrf1 responds to ER stress distinctly from Nrf2 that responds to mitochondrial ROS.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".