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Record W4241361370 · doi:10.1111/jdi.12008

President Lecture

2012· article· en· W4241361370 on OpenAlexaff
Nigishi Hotta

Bibliographic record

VenueJournal of Diabetes Investigation · 2012
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPeroxisome Proliferator-Activated Receptors
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsCitationMedicineLibrary scienceComputer science

Abstract

fetched live from OpenAlex

The extraordinary increase in diabetes worldwide is a matter of great urgency.Molecular biology and genetic approaches have greatly advanced our understanding of the causes of diabetes and its complications and the development of treatment.Despite these advances, the average age at death of Japanese patients with diabetes is still over 10 years younger than the general population in Japan for the period 1971-2000, although the lifespan of both males and females with diabetes has lengthened with time in parallel with that of the Japanese population.The most frequent cause of death was malignant neoplasia, with vascular disease the second highest in frequency during the period 1991-2000.Moreover, recently it has been well recognized that the prevalence of dementia is higher in diabetic patients than non-diabetic subjects.As a possibility promoting cognitive decline in diabetic state, brain insulin resistance associated from defective insulin signaling is proposed in the recent studies.Coupled with the aging of society, an increase in the number of elderly diabetic patients is inevitable.Therefore, in addition to the prevention and the treatment of diabetes mellitus and its vascular complications, the best treatment for dementia in elderly diabetic patients will be one of the most important issues in diabetes management in the future.From these points of view, the management of diabetes and its related problems are discussed, including the effect of polyol pathway hyperactivity in the pathogenesis of diabetic complications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.526
Threshold uncertainty score0.751

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0020.000
Scholarly communication0.0030.002
Open science0.0010.002
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.4740.278

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.229
Teacher spread0.220 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2012
Admission routes1
Has abstractyes

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