Activation of calcineurin in cancer: many paths, one hub
Bibliographic record
Abstract
Calcineurin is a calcium dependent serine/threonine phosphatase that integrates changes in intracellular calcium with downstream signaling pathways. A recent paper by Peuker et al . published in Nature Medicine identifies calcineurin as a key mediator of tumor growth and proliferation in response to altered stratification of the microbiota. Peuker et al . show that alterations in microbiota stratification activate toll-like receptor (TLR) signaling, which in turn activates calcineurin-NFAT signaling. While this is the first example of calcineurin activation in cancer through the intestinal microbiota, calcineurin is increasingly being recognized as a commonly activated target in cancer. Increases in intracellular calcium in response to hypoxic conditions, inflammation, and vascular endothelial growth factor signaling have all been demonstrated to result in increased calcineurin activation in malignant cells. More recently, cleavage of calcineurin has been associated with increased activity in cancer. Activation of calcineurin is implicated in signaling pathways promoting proliferation, migration, and metastasis. The elevated frequency of calcineurin activation in cancer highlights the importance of this pathway as a potential therapeutic target.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".