Bibliographic record
Abstract
Leporipoxvirus infection is restricted to lagomorphs (rabbits and hares) and gray squirrels. The genus is composed of four recognized members including Myxoma virus (MYXV), the type species, Rabbit fibroma virus (RFV), (also called Shope fibroma virus, SFV), Hare fibroma virus (FIBV) and Squirrel fibroma virus (SQFV). The genus has traditionally been found in the Americas (MYXV, SFV, SQFV) and Europe (FIBV). However, since the early 1900s MYXV has been employed in several countries to control the spread of feral European rabbits and can now be found enzootically in Australia and Europe. Based on sequencing data, the generic leporipoxvirus genome is approximately 160 kb and encodes between 165 genes (RFV/SFV) and 171 genes (MYXV). The best characterized Leporipoxvirus is MYXV. MYXV infection of its evolutionary host, Sylvilagus brasilensis, results in a cutaneous fibroma at the site of infection. This tumor resolves but clearance takes over a month. In contrast, MYXV infection of its pathological host, Oryctolagus cuniculus, results in a lethal disease called myxomatosis. This is a devastating infection that produces numerous tumors on the skin, ears, face and genital regions of the infected animal. Full-blown myxomatosis is most often fatal and is accompanied by the collapse of the host immune system. It is this close interaction between virus and host that has allowed researchers to identify a wide range of immune evasion molecules directed at numerous host immune pathways. To date, MYXV immunomodulators have been identified that target a variety of host cytokines, host cell signaling cascades, apoptosis and numerous sentinel immune molecules.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".