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QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science

2018· preprint· en· W4242789727 on OpenAlexaff
Evan Bolyen, Jai Ram Rideout, Matthew R. Dillon, Nicholas A. Bokulich, Christian C. Abnet, Gabriel A. Al‐Ghalith, Harriet Alexander, Eric J. Alm, Manimozhiyan Arumugam, Francesco Asnicar, Yang Bai, Jordan E. Bisanz, Kyle Bittinger, Asker Brejnrod, Colin Brislawn, C. Titus Brown, Benjamin J. Callahan, Andrés Mauricio Caraballo‐Rodríguez, John Chase, Emily K. Cope, Ricardo J.N. Bettencourt da Silva, Pieter C. Dorrestein, Gavin M. Douglas, Daniel M. Durall, Claire Duvallet, Christian F. Edwardson, Madeleine Ernst, Mehrbod Estaki, Jennifer Fouquier, Julia M. Gauglitz, Deanna L. Gibson, Antonio González, Kestrel Gorlick, Jiarong Guo, Benjamin Hillmann, Susan Holmes, Hannes Holste, Curtis Huttenhower, Gavin Huttley, Stefan Janssen, Alan K. Jarmusch, Lingjing Jiang, Benjamin D. Kaehler, Kyo Bin Kang, Christopher R. Keefe, Paul Keim, Scott T. Kelley, Dan Knights, Irina Koester, Tomasz Kościółek, Jorden Kreps, Morgan G. I. Langille, Joslynn S. Lee, Ruth E. Ley, Yongxin Liu, Erikka Loftfield, Catherine Lozupone, Massoud Maher, Clarisse Marotz, Bryan D Martin, Daniel McDonald, Lauren J. McIver, Alexey V. Melnik, Jessica L. Metcalf, Sydney Morgan, Jamie Morton, Ahmad Turan Naimey, José A. Navas-Molina, Louis‐Félix Nothias, Stephanie B. Orchanian, Talima Pearson, Samuel L Peoples, Daniel Petras, Mary L. Preuss, Elmar Pruesse, Lasse Buur Rasmussen, Adam R. Rivers, Michael S. Robeson, Patrick Rosenthal, Nicola Segata, Michael Shaffer, Arron Shiffer, Rashmi Sinha, Se Jin Song, John R. Spear, Austin D. Swafford, Luke Thompson, Pedro J. Torres, Anupriya Tripathi, Peter J. Turnbaugh, Sabah Ul-Hasan, Justin J. J. van der Hooft, Fernando Vargas, Yoshiki Vázquez‐Baeza, Emily Vogtmann, Max von Hippel, William A. Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C. Weber, Chase HD Williamson, Amy D. Willis, Zhenjiang Zech Xu, Jesse Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, J. Gregory Caporaso

Bibliographic record

Venuenot available
Typepreprint
Languageen
FieldDecision Sciences
TopicScientific Computing and Data Management
Canadian institutionsOkanagan University CollegeUniversity of British Columbia, Okanagan CampusUniversity of British ColumbiaDalhousie University
Fundersnot available
KeywordsMicrobiomeVisualizationComputer scienceScalabilityData scienceMetagenomicsModular designComputational biologyBiologyBioinformaticsData miningDatabase

Abstract

fetched live from OpenAlex

We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the microbiome research ecosystem, from scientists and engineers to clinicians and policy makers. QIIME 2 provides new features that will drive the next generation of microbiome research. These include interactive spatial and temporal analysis and visualization tools, support for metabolomics and shotgun metagenomics analysis, and automated data provenance tracking to ensure reproducible, transparent microbiome data science.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.021
metaresearch head score (Gemma)0.056
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Software · Consensus signal: none
Teacher disagreement score0.021
Threshold uncertainty score0.110

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0210.056
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0010.003
Bibliometrics0.0040.004
Science and technology studies0.0020.002
Scholarly communication0.0050.006
Open science0.0050.013
Research integrity0.0020.005
Insufficient payload (model declined to judge)0.0060.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.302
GPT teacher head0.460
Teacher spread0.158 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreSoftware

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations584
Published2018
Admission routes1
Has abstractyes

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