SAFETY EVALUATION OF FLAXSEED LIGNAN SUPPLEMENTATION IN OLDER ADULTS RESIDING IN LONG-TERM CARE HOMES
Bibliographic record
Abstract
The anti-inflammatory and anti-oxidant properties of flaxseed lignans could benefit age-related chronic conditions.We aimed to examine the safety of supplementation of the major flaxseed lignan, secoisolariciresinol diglucoside (SDG) in frail older adults residing in long-term care (LTC) homes.Twentysix older adults (60-80 years of age) met the inclusion criteria and were enrolled in a double blind randomized control trial of SDG supplementation at 300 mg/day for six months.Adverse events were recorded every week along with other blood and functionality tests.Participants in the treatment group demonstrated no evidence of hypoglycemia and hypotension or other adverse events.We conclude that SDG supplementation (300 mg/day) in a frail, complex patient population causes no significant adverse outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".