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Record W4243476872 · doi:10.1126/science.312.5772.343b

DATABASES: Protein Geography

2006· article· en· W4243476872 on OpenAlexaboutno aff

Bibliographic record

VenueScience · 2006
Typearticle
Languageen
FieldChemistry
TopicAdvanced Proteomics Techniques and Applications
Canadian institutionsnot available
Fundersnot available
KeywordsDatabaseGeographyComputer science

Abstract

fetched live from OpenAlex

The heart and the eye depend on different lineups of proteins, and so do a mitochondrion and a lysosome. But scientists haven't compiled a comprehensive list of the proteins residing in each type of organ and organelle. Two databases announced earlier this month in Cell take a step in that direction. Using mass spectrometry and other techniques, researchers with the Mouse Proteome Project* at the University of Toronto in Canada pinpointed more than 3200 proteins in six organs. The project's database indicates whether each protein is present in four cellular compartments, such as the cytoplasm and mitochondria. The Organelle Map Database† from the Max Planck Institute for Biochemistry in Martinsried, Germany, focuses on the mouse liver and caches results from a method called protein correlation profiling. The site maps some 1400 proteins to 10 cellular locations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Dataset · Consensus signal: Dataset
Teacher disagreement score0.111
Threshold uncertainty score0.370

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.015
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0110.018
Science and technology studies0.0020.001
Scholarly communication0.0060.006
Open science0.0050.005
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.1110.160

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.280
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreDataset

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2006
Admission routes1
Has abstractyes

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