34th International Winter Workshop / Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics
Bibliographic record
Abstract
Germ-cell tumors are relatively rare neoplasms that affect mostly young adults.The poor prognosis of these tumors has significantly improved after the advent of platinum compound, and most patients with metastatic germ cell tumors can be currently cured with combined modality treatment that comprises surgery, chemotherapy or radiotherapy.With the improved long-term prognosis, acute and chronic side effects of treatment represent an important issue.In the present study, we evaluated serum neopterin and plasma citrulline, a biomarker of gut damage in germ-cell tumor patients before and during 3 to 4 cycles of standard platinum-based chemotherapy.We report here the pilot results in the first 15 patients.Baseline serum neopterin concentrations were increased in a substantial proportion of patients, while plasma citrulline was mostly within the normal range.A significant negative correlation was observed between baseline serum neopterin and hemoglobin concentrations while positive concentration was noted between peripheral blood leukocyte count and neopterin.Changes in the investigated parameters were noted during the course of therapy.The study is ongoing.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.051 | 0.012 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".