The Influence Of The Epidermal Growth Factor Receptor On The DNA Damage Response As Examined Through Clathrin Affiliated Signalling Complexes
Bibliographic record
Abstract
The EGFR is an oncogene that when dysregulated, can cause tumour progression. Upon binding ligand, EGFR triggers activation of many signalling pathways including PI3K/Akt, RasErk, STAT, and PLCγ1. EGFR may also control DNA repair mechanism, although this remains poorly understood. Control of DNA repair by EGFR may be particularly relevant in the context of action and resistance of cancer drugs that cause DNA damage (eg. Cisplatin). I have examined how acute activation (10-30 minutes) of EGFR regulates DNA repair induced by cisplatin treatments and by examination of repair-markers such as γH2AX. I observed that as little as 10 minutes of EGF stimulation is sufficient to elicit remodelling of γH2AX in chronic cisplatin-treated cells. Using these methods, I dissected the EGFR signals and membrane traffic phenomena required for EGFR-dependent control of DNA repair. This work may reveal new ways to enhance the efficacy of existing chemotherapies, such as cisplatin, for cancer treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".