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Record W4244681705 · doi:10.32388/goe570

Methylenetetrahydrofolate Reductase

2020· article· en· W4244681705 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueDefinitions · 2020
Typearticle
Languageen
FieldMedicine
TopicFolate and B Vitamins Research
Canadian institutionsMcGill University Health Centre
Fundersnot available
KeywordsMethylenetetrahydrofolate reductaseChemistryGeneticsMedicineInternal medicineBiologyGeneAllele

Abstract

fetched live from OpenAlex

These are exciting times for those interested in the interaction of genetic and environmental factors in disease. Folic acid has recently gained a great deal of prominence as a biologically important molecule. The ingestion of folate before conception and continued during pregnancy can protect against both the occurrence and the recurrence of birth defects, in particular neural tube defects such as anencephaly and spina bifida.(n1) In addition, in recent years, homocysteine has been shown to be an independent risk factor for cerebrovascular, coronary artery and thrombotic diseases; folate is an effective way to lower levels of total plasma homocysteine (tHcy).(n2) A role for folate has also been proposed in the etiology and prevention of a wide variety of diseases including cancer and Alzheimer disease.(n3-n5)...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.543
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.219
GPT teacher head0.330
Teacher spread0.111 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it