Sugammadex for Rapid Intraoperative Reversal of Neuromuscular Blockade in a Neonate
Bibliographic record
Abstract
Sugammadex is a novel pharmacologic agent for the reversal of neuromuscular blockade, which selectively encapsulates the neuromuscular blocking agent (NMBA) thereby effectively removing it from the plasma concentration. In contrast to acetylcholinesterase inhibitors, sugammadex is able to reverse even profound neuromuscular blockade occurring immediately after the administration of a NMBA. Given this clinical effect, it has been suggested for use in critical clinical situations where rapid reversal of neuromuscular blockade is required. We report the use of sugammadex to reverse neuromuscular blockade following difficulty with positive pressure ventilation after endotracheal intubation in a neonate with a tracheoesophageal fistula. The potential for its use in critical airway and ventilation scenarios is reviewed. J Med Cases. 2018;9(12):400-402 doi: https://doi.org/10.14740/jmc3213
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".