Endometrioid Adenocarcinoma Arising From Adenomyosis in a Premenopausal Woman: A Case Report
Bibliographic record
Abstract
Endometrioid adenocarcinoma derived from adenomyosis is rare. A premenopausal woman, aged 36, was referred to us for evaluation of multiple solid tumors in the pelvis. MRI revealed multiple tumors in uterine myometrium and omentum. Their T2 and enhanced T1-weighted imaging led us to a diagnosis of uterine sarcoma. Hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and pelvic lymphadenectomy was performed. Histopathology revealed grade 3 endometrioid adenocarcinoma with squamous differentiation. Cancer nests were observed adjacent to the adenomyotic foci. Postoperative classification was pT3aN1M1. Rejecting adjuvant therapy, the patient died 16 days later from rapid enlargement and rupture of the metastasized liver and respiratory failure. An autopsy revealed mass lesions in the pelvic cavity and compressed small intestines causing ileus. Bone metastasis, multiple lymph node metastases including para-aortic, and lung metastases were also revealed. Multiple liver metastases had caused biliary obstruction and hepatic failure. The tumor-induced hypercoagulable condition resulted in multiple thromboses, which in turn led to hemorrhaging in the lungs and eventual respiratory failure. Histological examination of the pelvic mass lesions revealed mainly poorly differentiated carcinoma. The tumor cells contained bizarre nuclei and exhibited high mitotic activity. This case was high-potential malignant tumor as the tumor rapidly grew and infiltrated multiple organs in a short period. It was a type II carcinoma with biologically aggressive behavior. J Med Cases. 2015;6(12):554-558 doi: http://dx.doi.org/10.14740/jmc2357e
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".