Morphology‐Dependent Cell Imaging by Using a Self‐Assembled Diacetylene Peptide Amphiphile
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Herein, a novel cationic peptide gemini amphiphile containing diacetylene motifs ( DA 2 P ) is presented, which self‐assembles into novel tadpole‐ and bola‐shaped nanostructures at low concentrations and nanofibers at higher concentrations. Interestingly, the DA 2 P assemblies can be polymerized into a fluorescent red phase but only during incubation with HeLa cells, most likely owing to the reorganization of the diacetylene chains of DA 2 P upon interaction with the cell membrane. The red‐fluorescent polymerized DA 2 P assemblies can serve as a novel cell imaging probe. However, only vesicles, tadpole‐ and bola‐shaped DA 2 P assemblies can be translocated into HeLa cells, whereas the nanofiber‐like DA 2 P assemblies are trapped by the cell membranes and do not enter the cells. Hence, morphology‐dependent cell imaging is observed.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it