P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis
Bibliographic record
Abstract
Background: As the population ages the incidence of elderly onset inflammatory bowel disease (IBD) is expected to increase. In this study we compared clinical presentation and disease behaviour of IBD diagnosed in geriatric age (65 yrs ) vs adulthood (40-64 years). Methods: From January 2000 to May 2014 all patients diagnosed with IBD after the age of 65 were enrolled (elderly-onset IBD), each case was matched 1:1 by disease (UC or CD), gender and year of diagnosis with a control with IBD onset from 40 to 64 years (adult-onset IBD). Results: Table Symptoms at the presentation of UC and CD where similar between elderly and adults except for weight loss which was more common in elderly-onset UC and for constipation which was more frequent in elderly-onset CD. At the diagnosis of UC, higher proportion of elderly were classified as E2 and less as E1 according to Montreal Classification (65% vs 43%, p=0.02), while disease progression at maximum follow up was similar. For CD there were no differences between extension, phenotypes and histological activity between elderly and adults; disease progression was negligible. Therapy at the diagnosis and clinical behavior of UC and CD were similar between groups . Kaplan Meier analysis for time to first relapse showed no differences between elderly and adults neither for UC, nor for CD. Elderly onset UC, had a tendency to higher surgical approach (18% vs 8%, p=0.07). For CD, in both groups, about 50% of patients received surgical intervention but elderly onset CD were more likely to be operated early in the course of the disease; mean time to the surgical intervention was 1.51.9 months and 18.5 22.8 months, p=0.02 in elderly and adults respectively. Complications were more likely to occur among elderly-onset UC, we recorded an higher number of systemic infections (28% elderly VS 9% adults, p=0.027), deep vein thrombosis (14% elderly vs 1.5% adults, p= 0.003), intestinal complication (17% elderly vs 5% adults, p=0.022). Iatrogenic complications like steroidal diabetes, hypertension and osteoporosis occurred more frequently among elderly (17% vs 8%, p=0.029) Conclusions: Elderly-onset IBD seems to have similar presentation and clinical behaviour when compared to adult-onset IBD. Elderly IBD patients presents more comorbidities and are more likely to develop complications; these aspects needs to be taken into account when treating these patients
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".