A Synaptic and Systems Level Investigation of Memory Processes Using a Novel Multiple Memory Behavioural Procedure
Bibliographic record
Abstract
It is proposed that memories stabilize through synaptic and systems level consol- idation processes, forming long-lasting memory representations. Systems con- solidation models suggest that hippocampal contribution to memory storage dis- engages as time progresses, while ensembles of cortical neurons are proposed to form increasingly strong connections that store and represent remote memories as consolidation proceeds. Investigations into memory representations highlight discrepancies between the involvement of a cortical region in remote memory processes, the anterior cingulate cortex (ACC), and the hippocampus. The present thesis introduces a novel behavioural procedure that examines the ef- fect of increased processing demands on the hippocampus and the consequent effect on memory consolidation, storage and retrieval. Rats were trained on a single spatial task, two different spatial tasks, or one spatial and one non-spatial task. Regional involvement of the hippocampus and the ACC during retrieval were examined using immediate early genes and proteins of interest. Structural modifications in memory storage were examined using the Golgi-Cox method and quantification of dendritic complexity was an- alyzed through neuron reconstruction. The contribution of the ACC to spatial memory retrieval was assessed through behavioural performance and transient ACC pharmacological inactivation. The present thesis provides evidence that increased demand on the hip- pocampus results in accelerated processing of spatial memories. Findings show that the involvement of the ACC in memory processing can be manipulated by increasing hippocampal-processing demand. Functional, structural and be- havioral data suggest that taxing the demand on the hippocampus accelerates the involvement of the ACC. There is also evidence of continued hippocampal involvement in memory processes at recent and remote time points. Taken to- gether, these findings indicate an increased recruitment of the ACC, but not an accelerated independence from the hippocampus, in spatial memory processes. The use of a novel behavioral procedure aimed at increasing hippocampal- demand can reveal processes more similar to those present in the human con- dition, where there is a constant demand on memory systems. The novelty of the findings presented in this thesis will further our understanding of remote memory.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".