The Effect of Fasting on LH Secretion in Female Rats with Mutations to the Ghrelin Receptor Gene
Bibliographic record
Abstract
We investigated how ghrelin can mediate the inhibitory effects of fasting on the reproductive axis using female rats with a point mutation to the gene encoding GHSR.For this purpose, we fasted FHH GHSR KO rats and their WT counterparts starting on the evening of metestrus and ending 42h later on the expected proestrus afternoon.Rats were then euthanized; blood was collected and analyzed to compare plasma LH and estrogen concentrations between these animals and controls.Fasting significantly decreased LH concentrations in all rats regardless of their genotype.Interestingly, GHSR KO rats showed overall higher LH concentrations than WT rats regardless of their condition.Estrogen levels were not influenced by the genetic mutation and fasting.These findings suggest that ghrelin signalling is not required for a fastinginduced decrease in LH concentrations.However, ghrelin may modulate reproductive function as a negative feedback signal that reduces LH release regardless of energy state.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".