Lymphangiosarcoma Associated with Primary Lymphedema in a Bouvier des Flandres
Bibliographic record
Abstract
A 4-year-old, spayed female fawn Bouvier des Flandres presented to the Ontario Veterinary College Veterinary Teaching Hospital with a history of bilateral hind limb edema and an inguinal mass.The hind limb edema had been present since the dog was acquired at 8 weeks of age and was unchanged with time.Forty-five days before referral, a firm mass was noted in the left inguinal region.On presentation, the dog had bilateral, pitting, nonpainful edema of the hind limbs (Fig 1).The edema was marked below the tarsi but could be palpated into the inguinal region.Both sides appeared to be equally affected.The popliteal lymph nodes were not palpable, and the left hind limb was moist from the tarsus distally.Clear fluid was noted to be weeping from an area distal to the tarsus, and this finding was assumed to be lymphorrhea (leakage of lymph through the skin).On the basis of historic and physical examination findings, a tentative diagnosis of primary lymphedema was made.In addition, a firm, irregularly shaped approximately 4 ϫ 4-cm mass could be palpated in the left inguinal region.The mass extended dorsally toward the pelvis, and a dorsal margin could not be palpated.Initial diagnostic tests, including CBC, serum biochemistry, prothrombin and partial thromboplastin times, urinalysis, and 3-view thoracic radiography, were within normal limits.Cytologic evaluation of the lymphorrheic fluid indicated high cellularity composed of Ͼ95% small lymphocytes.An ultrasound examination of the abdomen and inguinal mass was performed.Abdominal ultrasonography showed no clinically relevant findings.Ultrasonography of the inguinal mass showed it to be a 3 ϫ 3-cm well-encapsulated lobulated mass that appeared to be extra-abdominal.An ultrasound examination was performed over both of the popliteal fossae, and popliteal lymph nodes could not be identified.Needle biopsies of the inguinal mass were obtained, and immunohistochemistry (including analysis for cytokeratin, vimentin, factor VIII-related antigen, and actin) was consistent with a diagnosis of hemangiosarcoma or lymphangiosarcoma.Lymphoscintigraphy of the hind limbs was performed and indicated a marked delay in lymphatic filling and an absence of popliteal lymph nodes.Results of lymphoscintigraphy confirmed the diagnosis of primary lymphedema.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.003 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.005 | 0.001 |
| Science and technology studies | 0.005 | 0.003 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".