Monitoring vascular changes induced by photodynamic therapy using contrast-enhanced micro-computed tomography
Bibliographic record
Abstract
The aim of this study is to determine if contrast-enhanced micro-computed tomography can be used to non-invasively image the response of vasculature in tumours that have been treated with photodynamic theraphy (PDT). The subjects used were C3H mice with RIF-1 tumour implanted subcutaneously and allowed to grow for 3 weeks prior to treatment. The subjects in this study were divided into PDT treated groups (150 J/cm², 50 J/cm²) and control groups (150 J/cm² light-only, untreated). The contast-enhanced micro-computed tomography imaging procedure consisted of eight-second scans taking place before treatment and up to 24 hours after treatment. The treatment response was evaluated through the ration of blood-to-tumour volume. Significant changes were detected at 8 and 24 hours in the 150 J/cm² PDT group (p< 0.01). Immunohistochemical staining confirmed the effects of each treatment in comparison to the control groups.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".