Changes in Cognitive Characteristics of Tg(APP)CRND8 Mice at Early Stages of Immunization with Beta‐Amyloid Peptide
Bibliographic record
Abstract
The progressive cognitive dysfunction of Alzheimer's disease is accompanied by a series of neuropathological changes including parenchymal and blood vessel deposition of Beta-amyloid peptide in the human brain. Many lines of evidence indicate that abnormal processing of Beta-amyloid peptide (a proteolytic derivative of the Beta-amyloid precursor protein, βAPP) plays a central role in initiating the pathogenesis of Alzheimer's disease. There is also strong support for the positive correlation between Beta-amyloid plaques and cognitive impairment in Alzheimer's disease patients. However, there are gaps in our knowledge of the pathogenesis of even the ‘simple’ genetic forms of Alzheimer's disease. Thus there has been a need for animal models that develop some or all aspects of this uniquely human disease in a reproducible fashion to decipher and stratify crucial pathogenic events.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".