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miRNA Biology

2010· book-chapter· en· W4249137255 on OpenAlexaff
Zhiguo Wang

Bibliographic record

VenueBENTHAM SCIENCE PUBLISHERS eBooks · 2010
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMicroRNA in disease regulation
Canadian institutionsUniversité de MontréalMontreal Heart Institute
Fundersnot available
KeywordsmicroRNASection (typography)BiologyFunction (biology)Transcription (linguistics)Computational biologyAction (physics)Psychological repressionGeneGeneticsGene expressionComputer sciencePhilosophyLinguistics

Abstract

fetched live from OpenAlex

This first chapter of the book aims to provide readers the basic information necessary for better understanding the contents of other chapters. The chapter begins with the stories or history of discovery of miRNAs. From this section, readers can get a sense on how some groundbreaking scientific findings could be achieved from small but mysterious things. In the second section, the whole pathway of biogenesis of miRNAs is described in detail, from transcription to maturation. This is followed by the section on action of miRNAs describing how mature miRNAs are hooked up to the protein complex and guide the complex to target genes to execute repression of gene expression at the post-transcriptional level. Finally, some important issues related to miRNA function are introduced in the section entitled “Some conceptual notes about miRNA function.”

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.039
Threshold uncertainty score0.130

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0030.002
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0390.046

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.248
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2010
Admission routes1
Has abstractyes

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