Hydroxyl radical: A possible mediator of nitroglycerin-induced vascular relaxation
Bibliographic record
Abstract
The endothelium-derived relaxing factor, nitric oxide (NO·), is involved in acetylcholine (Ach) and nitroglycerin (NTG)-induced relaxation of vascular smooth muscle. It is known that NO· interacts with the superoxide anion (O2·−) at physiological pH and this interaction leads to the generation of hydroxyl radicals (·OH). Hydroxyl radicals are known to induce dilation and act as mediators in acetylcholine (Ach)-induced relaxation of rabbit aortic smooth muscle. Thus, it was hypothesized that ·OH may be involved in NTG-induced relaxation. To test this hypothesis we investigated the effect of NTG on norepinephrine (NE)-precontracted isolated rabbit aortic rings in the absence and/or presence of O2·− [superoxide dismutase (SOD)] and ·OH scavengers [dimethylthiourea (DMTU) or mannitol]. Superoxide dismutase, DMTU, and mannitol markedly reduced NTG-induced relaxation of isolated rabbit aortic rings. Superoxide dismutase produced a 32% reduction in NTG-induced vasodilation. Pretreatment with DMTU and/or mannitol reduced NTG-induced relaxation by 56% and 49%, respectively. These results suggest that ·OH may be a mediator involved in NTG-induced vascular relaxation of rabbit aorta.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".