Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification
Bibliographic record
Abstract
Dehydroascorbic acid (DHAA) enters cells via Na + -independent glucose transporters (GLUT) and is converted to ascorbate.However, we found that Na + removal inhibited ["%C]DHAA uptake by smooth-muscle cells cultured from pig coronary artery.The uptake was examined for 2-12 min at 10-200 µM DHAA in either the presence of 134 mM Na + or in its absence (N-methyl glucamine, choline or sucrose replaced Na + ).This inhibition of DHAA uptake by Na + removal was paradoxical because it was inhibited by 2-deoxyglucose and cytochalasin B, as expected of transport via the GLUT pathway.We tested the hypothesis that this paradox resulted from an inefficient intracellular reduction of ["%C]DHAA into ["%C]ascorbate upon intracellular acidosis caused by the Na + removal.Consistent with this hypothesis : (i)Abbreviations used : DHAA, dehydroascorbic acid ; DOG, 2-deoxyglucose ; NMG, N-methyl D-glucamine + ; EIPA, ethylisopropyl amiloride. 1To whom correspondence should be addressed (e-mail groverak!
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".