Outcome Following Patent Ductus Arteriosus Ligation in Neonates-a 10 Year Multicenter Experience
Bibliographic record
Abstract
Rationale: The aim of this study was to determine the outcome following patent ductus arteriosus (PDA) ligation in neonates. Methods: This was a multicenter retrospective cohort study. Medical records from the neonatal intensive care unit of 3 hospitals from January 2008 to December 2017 were retrospectively reviewed and 233 neonates with PDA ligation were enrolled in this study. Results: Compared to neonates in 2008-2012, neonates in 2013-2017 underwent PDA ligation at an older ligation age (38 vs. 30 days), higher ligation weight (1432 vs. 1121g) and had a lower incidence of post ligation cardiac syndrome (PLCS) (35.0% vs. 49.2%). (p<0.001), but had no difference in mortality, length of hospital stay (LOS) or incidence of major complications (including NEC Stage III, ROP requiring intervention, severe BPD, PVL, and Grade III/IV-IVH). Compared to neonates with ligation age less than or equal to 28 days, neonates with a ligation age greater than 28 days had a higher incidence of BPD (98.5% vs. 89.9%) and severe BPD (60.4% vs. 44.4%; p<0.001), but had no difference in the incidence of PLCS, mortality, LOS or other major complications. Only 10.7% (25/233) of patients underwent direct laryngoscopy; in this subgroup, the incidence of VCP was 36.0% (9/25). Two patients were clinically diagnosed with VCP and not evaluated by laryngoscopy. In total, the incidence of VCP was 4.9% (11/233). There was no difference in ligation age and weight, mortality, LOS and major complications in neonates with or without VCP, or between infants with confirmed or suspected VCP (p>0.05). Conclusions: Over the last 10 years, there is a trend for neonates to undergo PDA ligation at an older age. However, this change in age of intervention was not associated with a significant change in the incidence of major complications apart from an increase seen in the incidence of severe BPD. The incidence of VCP in this cohort was low and had no effect on the infant outcomes examined.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".