Synthesis of 2,6‐dideoxy‐2‐fluoro‐6‐[<sup>18</sup>F]‐fluoro‐β‐D‐glucopyranosyl fluoride (2,6FGF) as a potential imaging probe for glucocerebrosidase
Bibliographic record
Abstract
Abstract We have previously synthesized 2‐deoxy‐2‐[ 18 F]‐fluoro‐β‐mannosyl [ 18 F]‐fluoride and shown that it behaves as a mechanism‐based inhibitor of Agrobacterium sp. β‐glucosidase. In‐vivo experiments indicate that this compound undergoes partial hydrolysis to produce 2‐deoxy‐2‐fluoro‐mannose, which can become phosphorylated and trapped within the cell. We now report the synthesis of another 2‐fluoro glycoside which is 18 F‐labelled at the 6 position so that the label cannot be lost during such glycoside hydrolysis and which, further, cannot be phosphorylated. The mechanism‐based glycosidase inhibitor 2,6‐dideoxy‐2‐fluoro‐6‐[ 18 F]‐fluoro‐β‐D‐glucopyranosyl fluoride (2,6FGF) was synthesized in 69% overall chemical yield and in 9% radiochemical yield (decay corrected) as a potential imaging probe for glycosidase. Copyright © 2001 John Wiley & Sons, Ltd.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".