Teratology Society: Platform sessions abstracts
Bibliographic record
Abstract
and Abnormal Cardiac Homeostasis in Adulthood 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and similar environmental contaminants have previously been demonstrated to be potent cardiovascular teratogens in developing piscine and avian species. In the current study, we investigate the effects of TCDD on murine cardiovascular development. Pregnant mice were dosed with 1.5, 3, 6, 12, and 24 ug/kg TCDD on gestation day (GD) 14.5. No overt maternal or fetal toxicity was seen at this dose, and litter size and neonatal survival were normal in the offspring of TCDD-treated dams. At day GD17.5, fetal mice exhibited a dose-related decrease in heart-to-body weight ratio that was significantly reduced at a dose as low as 3 ug/kg TCDD. In addition, cardiac proliferation, as measured by both proliferating cell nuclear antigen (PCNA) and 5-bromo-2'deoxyuridine (BrdU) staining, was reduced in GD17.5 hearts treated with 6 ug/kg TCDD. To determine if this reduction in cardiac weight was transient, or continued after birth, mice treated with 6 ug/kg TCDD were allowed to come to term and remain with the original dam. While heart weights had normalized by post-natal day 7, TCDD-treated mice had increased heart-to-body weight ratios and increased expression of the cardiac hypertrophy markers 21 days after birth. At postnatal day 21, mice from TCDD-treated dams demonstrated a pronounced ST-segment depression in response to isoproterenol, suggesting cardiac ischemia. Furthermore, basal and isoproterenol-responsive heart rate was lower in TCDD-treated mice. These results demonstrate that TCDD reduces heart weight during cardiac development, and results in a compensative cardiac hypertrophy and altered cardiac functionality after birth.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".