Teratology Society: Platform sessions abstracts
Bibliographic record
Abstract
In Utero and Lactational Exposure to 2,3,7,8-Tetrochlorodibenzo-p-dioxin in Mice Results in Reduced Developmental Cardiomyocyte Proliferation and Abnormal Cardiac Homeostasis in Adulthood 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and similar environmental contaminants have previously been demonstrated to be potent cardiovascular teratogens in developing piscine and avian species.In the current study, we investigate the effects of TCDD on murine cardiovascular development.Pregnant mice were dosed with 1.5, 3, 6, 12, and 24 ug/kg TCDD on gestation day (GD) 14.5.No overt maternal or fetal toxicity was seen at this dose, and litter size and neonatal survival were normal in the offspring of TCDD-treated dams.At day GD17.5, fetal mice exhibited a dose-related decrease in heart-to-body weight ratio that was significantly reduced at a dose as low as 3 ug/kg TCDD.In addition, cardiac proliferation, as measured by both proliferating cell nuclear antigen (PCNA) and 5-bromo-2'deoxyuridine (BrdU) staining, was reduced in GD17.5 hearts treated with 6 ug/kg TCDD.To determine if this reduction in cardiac weight was transient, or continued after birth, mice treated with 6 ug/kg TCDD were allowed to come to term and remain with the original dam.While heart weights had normalized by post-natal day 7, TCDD-treated mice had increased heart-to-body weight ratios and increased expression of the cardiac hypertrophy markers 21 days after birth.At postnatal day 21, mice from TCDD-treated dams demonstrated a pronounced ST-segment depression in response to isoproterenol, suggesting cardiac ischemia.Furthermore, basal and isoproterenol-responsive heart rate was lower in TCDD-treated mice.These results demonstrate that TCDD reduces heart weight during cardiac development, and results in a compensative cardiac hypertrophy and altered cardiac functionality after birth.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.278 | 0.141 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".