A Review of Non-Alcoholic Fatty Liver Disease: From Obesity to Liver Transplant
Bibliographic record
Abstract
Summary Non-alcoholic fatty liver disease (NAFLD) is becoming an increasingly common etiology of liver disease in the United States. As the prevalence of diabetes and obesity continues to increase, it will soon surpass hepatitis C as the most common etiology of end stage liver disease in the western world. NAFLD like many liver diseases can progress to cirrhosis, and patients often suffer morbidity secondary to the complications of portal hypertension. The exact percentage of hepatocellular carcinoma (HCC) that occurs in NAFLD patients is unknown, however, unlike many other liver diseases there is small potential for development of HCC independent of cirrhosis. Various conservative and pharmacologic therapies have been studied with varying degrees of efficacy including lifestyle modifications, bile acids, insulin sensitizers, vitamin E, and bariatric surgery. However, the only curative treatment for NAFLD cirrhosis is liver transplant. As the epidemic that is NAFLD continues to grow, more studies will need to be done to develop new therapies and curative treatments.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.005 | 0.005 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".