Integration of k-means clustering algorithm with network analysis for drug-target interactions network prediction
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Prediction of the interactions between drugs and target proteins is an important factor in silico drug discovery. The number of known interactions is very small in comparison to the potential number of interactions. In this paper, a new method is proposed which combines data from both chemical structures and genomic sequence data. This method uses both supervised and unsupervised learning, as well as network analysis techniques. The proposed approach integrates k-means clustering algorithm with Social Network Analysis (SNA) techniques for a novel prediction of drug-target interactions. Here, we demonstrate the performance of our approach in the prediction of drug-target interactions by using four classes of drug-target interaction networks in human; enzymes, ion channels, G protein-coupled receptors (GPCRs), and nuclear receptors. The AUC curve is used to evaluate the accuracy of the proposed approach using three classifiers; Bayes Network, Naïve Bayes and SVM. We could identify novel drug-protein interactions using the Bayes network classifier. The reported accuracy for enzymes, ion channels, GPCRs, and nuclear receptors are 98%, 85%, 98.6% and 99.2%.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it