Acquired Factor V Inhibitor Developing After Percutaneous Ethanol Injection Therapy for Hepatocellular Carcinoma
Bibliographic record
Abstract
We report a case of an 80-year-old man who showed an abrupt-onset prolongation of the prothrombin time (PT) and activated partial thromboplastin time (APTT) one month after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma. The patient had chronic hepatitis (not liver cirrhosis), but the liver function had been preserved before PEIT. Supplementation of vitamin K and fresh frozen plasma could not restore the coagulation disturbance, and the following examination revealed the existence of factor V inhibitors. Because the patient was positive for hepatitis C virus and concurrent with advanced chronic renal failure, a careful follow-up without any aggressive therapy, such as administration of steroids and other immunosuppressants, was selected. The PT and APTT had been gradually normalized in the following observation period for several months, and no serious event related to bleeding tendency had occurred. This is the first report of factor V inhibitors arising after PEIT that spontaneously diminished by no additional therapy. J Med Cases. 2011;2(3):132-137 doi: https://doi.org/10.4021/jmc214w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".