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Record W4253549935 · doi:10.32920/ryerson.14653443.v1

A fluid-structure interaction analysis of the human aortic arch under inertial load

2021· preprint· en· W4253549935 on OpenAlexafffund
Jonathan M Zalger

Bibliographic record

Venuenot available
Typepreprint
Languageen
FieldMedicine
TopicCardiovascular Health and Disease Prevention
Canadian institutionsToronto Metropolitan University
FundersNatural Sciences and Engineering Research Council of CanadaCompute Canada
KeywordsFluid–structure interactionPulsatile flowAortic archMechanicsInertial frame of referenceArchIsotropyFlow velocityFlow (mathematics)Immersed boundary methodPhysicsGeologyGeometryStructural engineeringBoundary (topology)MathematicsEngineeringAortaClassical mechanicsFinite element methodMathematical analysisMedicineSurgery

Abstract

fetched live from OpenAlex

Presented is an investigation into the use of numerical methods for modelling the effects of inertial load on the human cardiovascular system. An anatomically correct geometry was developed based on three-dimensional computed tomography (CT) data and independent meshes were created for the solid and fluid regimes. These domains were simulated using independent solvers and subsequently coupled using an intermediate data transfer alogrithm. At the inlet of the arch, a pulsatile velocity boundary condition was enforced replicating the cardiac cycle. Time invariant, resistive boundary conditions were used at all outlets and a linear isotropic constitutive model was used for tissue response. Verification was conducted by comparing simulation results at standard earth gravity (9.81 m/s²) with published values for velocity, mass flow rate, deformation, and qualitative flow behaviour. The presented fluid-structure interaction (FSI) model shows strong agreement with accepted normal values. Inertial load was then applied along the longitudinal axis of the arch in multiples of standard gravity to a maximum of 8+Gz. This load increased arch flow velocities, and reduced mass flow in the ascending brachiocephalic and carotid arteries. Blood flow from the arch to the upper body and brain ceased near 8+Gz. Although the presented results are preliminary, the feasibility of such an analysis has been successfully demonstrated.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.347
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes2
Has abstractyes

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