Annual Meeting of the International Academy of Cardiovascular Sciences: North American Section
Bibliographic record
Abstract
A wide variety of factors are considered to participate in the pathogenesis of peripheral artery disease (PAD) and different agents are being used for the treatment of this major health problem. Although reduction in blood flow due to narrowing of arteries in the ischemic limb is the major cause of PAD, none of the therapeutic interventions are satisfactory. We investigated the effects of CO 2 -water bath (CWB) therapy on blood flow in the ischemic hind limb. The femoral artery was occluded in rats to induce PAD and the animals were treated with or without CWB at 37C for 4 weeks (20 min/day; 5 days/week) starting one week after artery occlusion. Peaks, mean and minimal blood flows were not detected in the untreated ischemic hind limb of animals due to arterial ligation. However, blood flow values were about 50% of the control upon treatment with CWB; 67% of the ligated animals showed positive blood flow by CO 2 treatment. Morphological examination of the treated ischemic skeletal muscle revealed a 3-fold increase in small artery numbers indicating the formation of new blood vessels. Extensive studies have revealed that CO 2 at low concentrations serves as a redox sensitive signal transduction molecule for the genesis of angiogenesis. It is suggested that beneficial action of CO 2 therapy on blood flow to hind limb may be due to the development of angiogenesis in the ischemic skeletal muscle. session 2.1: Cerebrovascular diseases and stroke 002 large aNd sMall CereBrovasCular disease duriNg hyperTeNsioN
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".