The use of platelet monoamine oxidase-B as a biomarker for mercury neurotoxic effects among Inuit in Arctic Canada.
Bibliographic record
Abstract
Mercury (Hg) is a widespread neurotoxin, therefore it is important to identify a biomarker of effect in populations that could be at risk of Hg exposure. Platelet monoamine oxidase (MAO) could be a biomarker since animal studies indicate that brain and platelet MAO activity decreases as blood Hg increases. This study examined the relationship between blood Hg and platelet MAO activities among Inuit in the Canadian Arctic. This study found an increase in platelet MAO activities as blood Hg levels increased, which could be due to the high selenium (Se) in the population. This study then examined the relationship between Hg and MAO activities in an established cell line (SH-SY5Y) and found that Hg treated cells had an increase in MAO activities, but no changes occurred in MAO-A mRNA levels. Discrepancies between animal studies and these in vitro results could be due to differences between cell lines and whole organisms. --P.ii.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".