Remission of Chronic Acquired Demyelinating Polyneuropathy Associated With Paraproteinemia After Removal of Skull Plasmacytoma
Bibliographic record
Abstract
Chronic acquired demyelinating polyneuropathy can be caused by various etiologies. Although chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic acquired demyelinating polyneuropathy, currently there is no suitable biomarker to diagnose CIDP; hence misdiagnosis of CIDP has not been unusual. Herein, we present a patient with initially presumed CIDP, who maintains disease remission after early surgical removal of solitary plasmacytoma during 1-year follow-up. A 55-year-old woman was referred to our hospital due to progressive upper and lower extremity weakness from 6 months ago. Nerve conduction study findings were compatible with acquired demyelinating polyneuropathy, fulfilling electrodiagnostic criteria of CIDP. Serum electrophoresis suggested monoclonal gammopathy of lambda type, but the bone marrow biopsy showed no evidence of neoplastic plasma cell infiltration. Brain magnetic resonance imaging revealed an osteolytic mass involving the right parietal skull and adjacent dura mater. Total excision of the skull mass was performed. The biopsy result was compatible with plasmacytoma. Even without long term administration of high dose corticosteroid, the patient not only has continued to improve clinically, but also showed markedly improved electrophysiological findings during 1-year follow-up. J Neurol Res. 2017;7(6):108-111 doi: https://doi.org/10.14740/jnr462w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".